Cellular models provide a comprehensive, efficient and cost-effective way of studying human diseases. We culture primary cells derived from patients, iPSCs and established cell lines to understand molecular mechanisms of disease, study drug interactions and discover biomarkers. Using technologies like SILAC, CRISPR-Cas9, metabolic labeling and drug treatment, we investigate living cells and use them in several ways for downstream analysis including proteomic, lipidomic and metabolomic studies. We are studying many diseases using cellular models, including cancers, chromosomal anomalies and several rare single-gene disorders.